In an unusual twist, this phrase in its origin is definitely negative with the angel describing the future of Ishmael as one who will take what he wants and will step on anyone who gets in his way (Genesis 16:12). However, in recent years it has turned semi-positive and can refer to someone who is a go-getter and doesn’t just stick to one direction. For an example, an industrialist may concentrate not only on textiles but may also be involved in electronics. It still can describe someone in a slightly negative manner as in an over-ambitious city councilman who is on every committee to make sure that everyone knows who he is.

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